Abstract
Peroral administration of Vilon (Lys-Glu) to male and female Wistar rats aging 3 and 11 months changed activity of digestive enzymes (invertase, maltase, alkaline phosphatase, and amino- and dipeptidases) in various portions of the gastrointestinal tract. The increase in enzyme activity was most pronounced in 11-month-old animals, which diminished differences between rats of various ages. Our results indicate that Vilon produces positive effects on digestive enzyme activity during aging.
MeSH terms
-
Adjuvants, Immunologic / administration & dosage
-
Adjuvants, Immunologic / pharmacology*
-
Administration, Oral
-
Aging / drug effects
-
Aging / metabolism*
-
Alkaline Phosphatase / metabolism
-
Aminopeptidases / metabolism
-
Animals
-
Digestive System / drug effects
-
Digestive System / enzymology*
-
Dipeptidases / metabolism
-
Dipeptides / administration & dosage
-
Dipeptides / pharmacology*
-
Female
-
Glycoside Hydrolases / metabolism
-
Male
-
Rats
-
Rats, Wistar
-
alpha-Glucosidases / metabolism
-
beta-Fructofuranosidase
Substances
-
Adjuvants, Immunologic
-
Dipeptides
-
Alkaline Phosphatase
-
Glycoside Hydrolases
-
alpha-Glucosidases
-
beta-Fructofuranosidase
-
Aminopeptidases
-
Dipeptidases
-
lysylglutamic acid