Dystonia as acute adverse reaction to cough suppressant in a 3-year-old girl

Eur J Paediatr Neurol. 2001;5(4):167-8. doi: 10.1053/ejpn.2001.0498.


Cough suppressant preparations containing mixtures of dextromethorphan or codeine with antihistamines, decongestants (sympathomimetic), expectorants and antipyretics with either sedative or anticholinergic activity have been associated with dystonic reactions in children. We report on a 3-year-old girl who presented with episodic stiffness and abnormal posturing with rigidity after arbitrary maternal administration of a mixture of methylcodeine and extract from Hedera plant.

Publication types

  • Case Reports

MeSH terms

  • Antitussive Agents / adverse effects*
  • Child, Preschool
  • Codeine / adverse effects*
  • Drug Combinations
  • Dystonia / chemically induced*
  • Female
  • Humans
  • Plant Extracts / adverse effects*
  • Suppositories


  • Antitussive Agents
  • Drug Combinations
  • Plant Extracts
  • Suppositories
  • Codeine