The effect of dietary intervention on lipid profiles in individuals with spinal cord injury

J Spinal Cord Med. Spring 2001;24(1):26-9. doi: 10.1080/10790268.2001.11753551.


Objective: The purpose of this study was to evaluate the effects of a simple dietary intervention for individuals with chronic spinal cord injury (SCI) and moderately elevated total cholesterol.

Methods: Baseline and follow-up serum lipid values were obtained on 222 persons with SCI. Eighty-six individuals with total cholesterol >200 mg/dL were referred for dietary consultation (group 1). The remainder with values <200 mg/dL and no consultation served as controls (group 2).

Results: At average follow-up of 16 months, group 1 demonstrated significant declines in total cholesterol and low-density lipoprotein cholesterol (LDL-C), whereas group 2 demonstrated significant increases in total cholesterol. Triglyceride levels followed similar but nonsignificant patterns. There were no significant changes in high-density lipoprotein cholesterol for either group. In group 1, 17% had clinically significant reductions in total cholesterol to <200 mg/dL and 21% had reductions of LDL-C from >135 mg/dL to <135 mg/dL.

Conclusions: Dietary intervention should be an initial treatment for those with SCI and moderately elevated total cholesterol, with the expectation that approximately 20% will respond favorably.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / diet therapy*
  • Cholesterol / blood*
  • Cohort Studies
  • Female
  • Humans
  • Lipids / blood*
  • Lipoproteins / blood*
  • Male
  • Middle Aged
  • Paraplegia / diet therapy*
  • Spinal Cord Injuries / blood
  • Spinal Cord Injuries / diet therapy*


  • Lipids
  • Lipoproteins
  • Cholesterol