[Psychotropic effects of alkaloid lappaconitine and its various derivatives]

T G Tolstikova; T V Voevoda; M P Dolgikh

[Psychotropic effects of alkaloid lappaconitine and its various derivatives]

Eksp Klin Farmakol. 2001 Jul-Aug;64(4):7-9.

[Article in Russian]

Authors

T G Tolstikova¹, T V Voevoda, M P Dolgikh

Affiliation

¹ Department of Natural and Biologically Active Compounds, Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr. akad. Lavrent'eva 9, Novosibirsk, 630090 Russia.

PMID: 11589117

Abstract

The psychotropic activity of (I, base), its N-oxide, and a complex of the base with 18-alpha-H-glycyrrhizic acid (1:2) was studied. It was established that I and its N-oxide exhibit dopaminopositive effect whereas the complex produces a serotoninopositive effect. Toxicities of the lipophilic I is half that of the hydrophilic; toxicity of N-oxide and the complex are 60 and 100 times lower than the activity of lappaconitine (base).

Publication types

English Abstract

MeSH terms

Acetylcholine / antagonists & inhibitors
Aconitine / analogs & derivatives
Aconitine / pharmacology*
Aconitine / toxicity
Animals
Blepharoptosis / chemically induced
Cholinergic Agents / pharmacology
Cyclic N-Oxides / pharmacology
Cyclic N-Oxides / toxicity
Lethal Dose 50
Male
Mice
Motor Activity / drug effects
Nicotine / antagonists & inhibitors
Pentylenetetrazole / antagonists & inhibitors
Psychotropic Drugs / pharmacology*
Psychotropic Drugs / toxicity
Reserpine / antagonists & inhibitors
Sleep / drug effects
Stereotyped Behavior / drug effects

Substances

Cholinergic Agents
Cyclic N-Oxides
Psychotropic Drugs
Nicotine
Reserpine
Acetylcholine
Pentylenetetrazole
Aconitine
lappaconitine