Management of conjunctival and corneal melanoma with surgical excision, amniotic membrane allograft, and topical chemotherapy

Am J Ophthalmol. 2001 Oct;132(4):576-8. doi: 10.1016/s0002-9394(01)01085-6.


Purpose: To illustrate a novel method of management for extensive conjunctival and corneal melanoma.

Methods: Interventional case report. A 40-year-old Caucasian woman presented with a large, diffuse conjunctival melanoma involving 6 clock hours of the limbus. The remaining bulbar conjunctiva and the entire corneal epithelium were affected by diffuse, flat melanosis.

Results: The conjunctival melanoma was completely resected microsurgically in one piece without disrupting the tumor. The conjunctival melanosis was treated with double freeze-thaw cryotherapy. The extensive conjunctival defect, involving one-half of the bulbar conjunctiva, was reconstructed with an amniotic membrane allograft. The corneal melanosis was subsequently treated with topical mitomycin C eyedrops. At 8 months follow-up, the conjunctiva and the cornea were completely healed with resolution of all pigment and 20/20 visual acuity.

Conclusion: Preliminary evidence suggests that combined therapeutic approaches, consisting of extensive tumor removal, cryotherapy, amniotic membrane allograft, and topical mitomyin C, can be effective in the management of diffuse conjunctival and corneal melanoma arising from primary acquired melanosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amnion / transplantation*
  • Antibiotics, Antineoplastic / therapeutic use*
  • Combined Modality Therapy
  • Conjunctival Neoplasms / therapy*
  • Corneal Diseases / therapy*
  • Female
  • Humans
  • Melanoma / therapy*
  • Melanosis / therapy*
  • Mitomycin / therapeutic use*
  • Ophthalmologic Surgical Procedures*
  • Transplantation, Homologous


  • Antibiotics, Antineoplastic
  • Mitomycin