Evidence for gradients of gene expression correlating with zonal topography of the olfactory sensory map

Mol Cell Neurosci. 2001 Sep;18(3):283-95. doi: 10.1006/mcne.2001.1019.

Abstract

Signals regulating diversification of olfactory sensory neurons to express odorant receptors and other genes necessary for correct assembly of the olfactory sensory map persist in the olfactory epithelium of adult mouse. We have screened for genes with an expression pattern correlating with the topography odorant receptor-expression zones. The Msx1 homeobox gene and a semaphorin receptor (Neuropilin-2) showed graded expression patterns in the olfactory epithelium. The gradients of Msx1 and Neuropilin-2 expression in basal cells and neurons, respectively, correlated with expression of a retinoic acid-synthesizing enzyme (RALDH2) in lamina propria. A BMP-type I receptor (Alk6) showed a reverse gradient of expression in the supporting cells of the epithelium. Considering known functions of identified genes in cell specification and axon guidance this suggests that zonal division of the olfactory sensory map is maintained, during continuous neurogenesis, as a consequence of topographic counter gradients of positional information.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activin Receptors, Type I / biosynthesis
  • Activin Receptors, Type I / genetics
  • Aldehyde Oxidoreductases / biosynthesis
  • Aldehyde Oxidoreductases / genetics
  • Animals
  • Bone Morphogenetic Protein Receptors, Type I
  • Gene Expression / physiology*
  • Homeodomain Proteins / biosynthesis
  • Homeodomain Proteins / genetics
  • MSX1 Transcription Factor
  • Mice
  • Mice, Inbred C57BL
  • Nasal Cavity / cytology
  • Nasal Cavity / innervation*
  • Nasal Cavity / metabolism*
  • Nerve Tissue Proteins / biosynthesis
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Neuropilin-1
  • Olfactory Mucosa / metabolism
  • Olfactory Receptor Neurons / metabolism*
  • Protein-Serine-Threonine Kinases*
  • Receptors, Growth Factor*
  • Retinal Dehydrogenase
  • Transcription Factors*

Substances

  • Homeodomain Proteins
  • MSX1 Transcription Factor
  • Nerve Tissue Proteins
  • Receptors, Growth Factor
  • Transcription Factors
  • Neuropilin-1
  • Aldehyde Oxidoreductases
  • Retinal Dehydrogenase
  • Protein-Serine-Threonine Kinases
  • Activin Receptors, Type I
  • Bmpr1b protein, mouse
  • Bone Morphogenetic Protein Receptors, Type I