[Risk factors and coronary morbimortality in a Mediterranean industrial cohort over 28 years of follow-up. The Manresa Study]

Rev Esp Cardiol. 2001 Oct;54(10):1146-54. doi: 10.1016/s0300-8932(01)76472-x.
[Article in Spanish]


Objective: To study the incidence and mortality of coronary heart disease (CHD) and all-cause mortality in a cohort of men followed during 28 years, and their association with serum cholesterol, systolic blood pressure, glycemia, cigarette smoking and body mass index measured at baseline.

Research design and methods: A cohort of 1,059 men aged 30 to 59 years and free of cardiovascular diseases at baseline in 1968, was examined every five years until 1988. The last examination was performed in 1996. Information was collected in 96.4% of the participants.

Results: Incidence and mortality rates from CHD and from all-causes of death per 105 person-years of observation were 499.80, 235.80 and 925.33, respectively. At the end of follow-up, high levels of serum cholesterol and smoking were independently associated with the incidence and mortality from CHD adjusted for age, blood pressure, glycemia and BMI. Serum cholesterol, hyperglycemia and smoking were independently associated with all-cause mortality.

Conclusions: In this industrial cohort of men, with a relatively low incidence of CHD, smoking and serum cholesterol at baseline were independently associated with the incidence of CHD over 28 years of observation.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Distribution
  • Blood Glucose / metabolism
  • Body Mass Index
  • Cholesterol / blood
  • Cohort Studies
  • Coronary Disease / epidemiology
  • Coronary Disease / etiology*
  • Coronary Disease / mortality*
  • Death, Sudden, Cardiac
  • Follow-Up Studies
  • Humans
  • Hypertension / complications
  • Incidence
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk Factors
  • Smoking / adverse effects
  • Spain / epidemiology


  • Blood Glucose
  • Cholesterol