Reversible posterior leukoencephalopathy syndrome: a report of 2 cases

Neurol India. 2001 Sep;49(3):311-3.


Reversible posterior leukoencephalopathy syndrome (RPLE) is an increasingly recognised disorder, most commonly associated with malignant hypertension, toxaemia of pregnancy or the use of immunosuppressive agents. Two cases of RPLE syndrome occurring in the setting of accelerated hypertension and eclampsia are described. Both patients had seizures, altered sensorium and typical findings on neuroimaging. They had complete clinical and radiological recovery. The clinical course, pathophysiology and neuroimaging features of RPLE syndrome are discussed.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Eclampsia / complications*
  • Female
  • Humans
  • Hypertensive Encephalopathy / complications*
  • Hypertensive Encephalopathy / diagnostic imaging
  • Hypertensive Encephalopathy / physiopathology
  • Pregnancy
  • Seizures / etiology
  • Syndrome
  • Tomography, X-Ray Computed