Aberrant Expression of p21(WAF1/CIP1) and p27(KIP1) in Cervical Carcinoma

Cancer Lett. 2001 Oct 22;172(1):93-8. doi: 10.1016/s0304-3835(01)00624-3.

Abstract

An immuno-histochemical study of p21 and p27 expression in cervical carcinoma was performed in 73 patients. Positive p21 and p27 staining was detected in 35.6 and 11% of tumour tissues, respectively. p21 expression was significantly correlated with advanced disease stage and negative human papilloma virus infection whilst positive p27 staining was not correlated with any clinical and pathological parameters studied. Kaplan-Meier estimation indicated that survival might be related to disease stage, tumour grade and p21 expression. Cox regression analysis confirmed that advanced stage disease and poorly differentiated tumour are independent prognostic factors for cervical carcinoma.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Carcinoma / diagnosis
  • Carcinoma / metabolism*
  • Carcinoma / virology
  • Cell Cycle Proteins / biosynthesis*
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclin-Dependent Kinase Inhibitor p27
  • Cyclins / biosynthesis*
  • Down-Regulation
  • Female
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Models, Statistical
  • Papillomaviridae / metabolism
  • Prognosis
  • Regression Analysis
  • Tumor Suppressor Proteins*
  • Up-Regulation
  • Uterine Cervical Neoplasms / diagnosis
  • Uterine Cervical Neoplasms / metabolism*
  • Uterine Cervical Neoplasms / virology

Substances

  • CDKN1A protein, human
  • Cell Cycle Proteins
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins
  • Tumor Suppressor Proteins
  • Cyclin-Dependent Kinase Inhibitor p27