Abstract
Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA.
MeSH terms
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Amino Acid Sequence
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Crystallography, X-Ray
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DNA Damage
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DNA Repair
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DNA Replication
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DNA-Directed DNA Polymerase / chemistry*
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DNA-Directed DNA Polymerase / metabolism*
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Humans
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Models, Molecular
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Molecular Sequence Data
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Mutation
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Protein Conformation
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Protein Structure, Tertiary
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Sequence Alignment
Substances
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DNA-Directed DNA Polymerase