Error-prone DNA polymerases: novel structures and the benefits of infidelity

Cell. 2001 Oct 5;107(1):9-12. doi: 10.1016/s0092-8674(01)00509-8.


Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA.

Publication types

  • Comment
  • Review

MeSH terms

  • Amino Acid Sequence
  • Crystallography, X-Ray
  • DNA Damage
  • DNA Repair
  • DNA Replication
  • DNA-Directed DNA Polymerase / chemistry*
  • DNA-Directed DNA Polymerase / metabolism*
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Mutation
  • Protein Conformation
  • Protein Structure, Tertiary
  • Sequence Alignment


  • DNA-Directed DNA Polymerase