Principles of glutamatergic synapse formation: seeing the forest for the trees

Curr Opin Neurobiol. 2001 Oct;11(5):536-43. doi: 10.1016/s0959-4388(00)00246-4.


General principles regarding glutamatergic synapse formation in the central nervous system are beginning to emerge. These principles concern the specific roles that dendrites and axons play in the induction of synaptic differentiation, the modes of presynaptic and postsynaptic assembly, the time course of synapse formation and maturation, and the roles of synaptic activity in these processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Dendrites / physiology
  • Glutamic Acid / physiology*
  • Humans
  • Presynaptic Terminals / physiology
  • Receptors, Glutamate / physiology
  • Synapses / physiology*


  • Receptors, Glutamate
  • Glutamic Acid