Detection of Mycoplasma pneumoniae DNA in cerebrospinal fluid of a patient with M. pneumoniae infection-"associated" stroke

Clin Infect Dis. 2001 Nov 15;33(10):E119-21. doi: 10.1086/323461. Epub 2001 Oct 5.


A 36-year-old woman presented with an acute ischemic stroke and a concomitant Mycoplasma pneumoniae infection that had been proven clinically, bacteriologically, and serologically. M. pneumoniae DNA was demonstrated in cerebrospinal fluid by positive nested polymerase chain reaction, and intrathecal antibody production was also detected. Contrary to previous reports about M. pneumoniae-associated stroke, most thrombostatic abnormalities in this patient occurred after stroke onset. Although the cause of stroke remains unclear in this patient, central nervous system invasion of M. pneumoniae DNA has to be considered a possible cause in rare cases of cerebral ischemia.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • DNA, Bacterial / cerebrospinal fluid*
  • Female
  • Humans
  • Mycoplasma pneumoniae / genetics
  • Mycoplasma pneumoniae / isolation & purification*
  • Pneumonia, Mycoplasma / complications*
  • Pneumonia, Mycoplasma / microbiology
  • Polymerase Chain Reaction
  • Stroke / microbiology*


  • DNA, Bacterial