Analysis of tauopathies with transgenic mice

Trends Mol Med. 2001 Oct;7(10):467-70. doi: 10.1016/s1471-4914(01)02123-2.

Abstract

Intraneuronal filamentous inclusions composed of the microtubule-associated protein tau are a feature of several neurodegenerative diseases (including Alzheimer's disease) known as tauopathies. A pivotal finding was the identification in 1998 of mutations in tau associated with frontotemporal dementia with parkinsonism linked to chromosome 17. This demonstrated that tau dysfunction is sufficient to cause neurodegeneration, and indicated that tau is likely to play a crucial role in the pathogenesis of other tauopathies. However, the mechanism by which tau filamentous lesions form and their role in neurodegeneration remains uncertain. Recent progress in the development of transgenic mouse models of human tauopathy is allowing these questions to be addressed.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Glycogen Synthase Kinase 3
  • Mice
  • Mice, Transgenic
  • Microtubule-Associated Proteins / metabolism
  • Neurofibrils / pathology
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • Tauopathies / genetics*
  • Tauopathies / metabolism*
  • Tauopathies / pathology
  • Transgenes / genetics
  • Up-Regulation
  • tau Proteins / genetics
  • tau Proteins / metabolism*

Substances

  • MAPT protein, human
  • Microtubule-Associated Proteins
  • tau Proteins
  • Protein-Serine-Threonine Kinases
  • Glycogen Synthase Kinase 3
  • tau-protein kinase