Bradykinin B2BKR receptor polymorphism and left-ventricular growth response

Lancet. 2001 Oct 6;358(9288):1155-6. doi: 10.1016/s0140-6736(01)06273-0.


Angiotensin-converting-enzyme (ACE) activity regulates left-ventricular growth. The deletion (D), rather than the insertion (I), ACE gene variant is associated with increased ACE activity and kinin degradation, and the absence (-) rather than the presence (+) of a 9 bp deletion in the gene encoding the bradykinin 2 receptor (B2BKR) is associated with greater gene expression. We determined the ACE and B2BKR genotype of 109 male army recruits, and measured their physiological left-ventricular growth response to a 10-week physical training programme. Mean left-ventricular growth was 15.7 g (SE 3.5) in those with ACE genotype D/D and B2BKR genotype +9/+9, but -1.37 g (4.1) in those with ACE genotype I/I and B2BKR genotype -9/-9 (p=0.003 for trend across genotypes). These results suggest that kinins regulate left-ventricular growth, mediating some of the effects of ACE in this regard.

Publication types

  • Letter

MeSH terms

  • Adult
  • Exercise
  • Genotype
  • Heart Ventricles / growth & development*
  • Humans
  • Male
  • Peptidyl-Dipeptidase A / genetics*
  • Polymorphism, Genetic
  • Receptor, Bradykinin B2
  • Receptors, Bradykinin / genetics*


  • Receptor, Bradykinin B2
  • Receptors, Bradykinin
  • Peptidyl-Dipeptidase A