Photoradiation therapy. II. Cure of animal tumors with hematoporphyrin and light

J Natl Cancer Inst. 1975 Jul;55(1):115-21. doi: 10.1093/jnci/55.1.115.

Abstract

Exposure of mouse and rat tumors of various types to more than 600 nm light 24 or 48 hours after an injection of hematoporphyrin resulted in a substantial number of long-term cures. Since hematoporphyrin is preferentially retained in tumor tissue, selective tumor destruction could be obtained. Light penetration studies and the high efficiency of this technique indicated its applicability even to certain deep-seated human tumors.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Carcinosarcoma / therapy*
  • Dose-Response Relationship, Drug
  • Dose-Response Relationship, Radiation
  • Hematoporphyrins / metabolism
  • Hematoporphyrins / therapeutic use*
  • Hematoporphyrins / toxicity
  • Light / adverse effects
  • Liver / metabolism
  • Mammary Neoplasms, Experimental / therapy*
  • Mice
  • Mice, Inbred DBA
  • Neoplasms / metabolism
  • Neoplasms, Experimental
  • Phototherapy*
  • Rats
  • Time Factors

Substances

  • Hematoporphyrins