The biologic basis of fatigue

Cancer. 2001 Sep 15;92(6 Suppl):1678-83. doi: 10.1002/1097-0142(20010915)92:6+<1678::aid-cncr1496>;2-r.


In spite of many remarkable advances in our understanding of the mechanisms of cancer biology, very little attention has been directed toward mechanisms underlying cancer-induced symptoms. Although fatigue is a widely prevalent complication of cancer, there is a paucity of both basic and clinical research in this area. This article details our current knowledge of mechanisms causing cancer-related fatigue and briefly discusses currently available therapeutic options. A framework for addressing gaps in our knowledge and recommendations for future research directions are proposed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Fatigue / etiology*
  • Humans
  • Neoplasms / complications*
  • Neoplasms / physiopathology