Objective: To study the anti-oxidative action of GCS in the tissues of mice.
Method: Contents of superoxide dismutase (SOD), malondialdehyde (MDA) and lipofuscin in the heart, liver, brain and kidney of mice were measured, using pyrogallic acid, thiobarbi turic acid(TBA) and fluorescent technique respectively.
Result: It was found that the GCS (125 mg/kg, 250 mg/kg) had a significantly higher SOD activity and lower MDA contents in brain and kidney than that in control group. GCS(250 mg/kg) enhanced SOD activity in the heart and liver, declined contents of MDA and lipofuscin in all tissues.
Conclusion: The results suggest that GCS could increase the antioxidative action in vivo significantly and prevent lipoperoxidative damages in tissues.