Elevated substance P levels in HIV-infected men

AIDS. 2001 Oct 19;15(15):2043-5. doi: 10.1097/00002030-200110190-00019.


The neuropeptide, substance P, is a potent modulator of neuroimmunoregulation. Substance P and its receptor modulate HIV infection. HIV-seropositive men had significantly higher plasma substance P levels compared with uninfected controls, which were associated with decreased CD16 and CD56 natural killer (NK) cell populations. The changes in plasma substance P levels and decreases in NK subsets did not correlate with CD4 cell levels, but a diurnal pattern was suggested for substance P. The balance between substance P expression and functions of immune cells may be important in the immunopathogenesis of HIV infection.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cohort Studies
  • Flow Cytometry
  • HIV Infections / blood*
  • HIV Infections / immunology
  • HIV Seronegativity
  • Homosexuality
  • Humans
  • Killer Cells, Natural
  • Male
  • Substance P / blood*


  • Substance P