Plexin signaling via off-track and rho family GTPases

Neuron. 2001 Oct 11;32(1):1-3. doi: 10.1016/s0896-6273(01)00459-7.


Two papers in this issue of Neuron examine new aspects of Semaphorin signaling via Plexin receptors. Winberg et al. present evidence that the transmembrane protein Off-track (OTK) interacts biochemically and genetically with Plexin A and is important for Sema 1a repulsive signaling. Hu et al. examine the coupling of Plexin B to Rac and RhoA and propose that Plexin B signaling involves inhibition of Rac function by direct sequestration and simultaneous activation of RhoA.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Cell Adhesion Molecules / physiology*
  • Drosophila Proteins*
  • Membrane Proteins / physiology*
  • Nerve Tissue Proteins / physiology*
  • Protein-Tyrosine Kinases*
  • Receptors, Fibroblast Growth Factor*
  • Signal Transduction / physiology*
  • rho GTP-Binding Proteins / physiology*


  • Cell Adhesion Molecules
  • Drosophila Proteins
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Receptors, Fibroblast Growth Factor
  • plexin
  • Protein-Tyrosine Kinases
  • htl protein, Drosophila
  • rho GTP-Binding Proteins