Serum alpha-1-antitrypsin concentration during normal and diabetic pregnancy

Eur J Obstet Gynecol Reprod Biol. 2001 Nov;99(1):53-6. doi: 10.1016/s0301-2115(01)00356-6.


Objectives: The aim of this study was a comparison of serum alpha-1-antitrypsin (AAT) concentration in the course of normal and diabetic pregnancy.

Methods: Serum AAT concentration was determined on NOR-Partigen plates (Behring Diagnostics GmbH, Marburg). The studied material included healthy women without pregnancy (n=14), healthy pregnant women in the first trimester (n=12), second trimester (n=15), third trimester (n=15), and 16 pregnant women with type-1 diabetes mellitus studied prospectively in successive stages of pregnancy.

Results: In the first trimester of normal pregnancy, a significant increase of serum AAT concentration was observed in comparison with healthy women without pregnancy (P<0.01). In all stages of pregnancy with type-1 diabetes mellitus, a higher increase of AAT concentration was found as compared with healthy pregnant women (P<0.0001), especially in third trimester. There was no correlation shown between concentration of AAT and fructosamine in the serum of healthy and diabetic pregnant women (P>0.05).

Conclusions: During normal and diabetic pregnancy, an increase of serum AAT concentration occurred with the regression lines exhibiting a different slopes. The highest AAT concentration was observed in third trimester of diabetic pregnancy. Increase in concentration of AAT in the serum of pregnant women with diabetes does not depend on the value of glycaemic control.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Diabetes Mellitus, Type 1 / blood*
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / drug therapy
  • Female
  • Fructosamine / blood
  • Humans
  • Insulin / therapeutic use
  • Pregnancy / blood*
  • Pregnancy Trimesters
  • Pregnancy in Diabetics / blood*
  • Pregnancy in Diabetics / drug therapy
  • Reference Values
  • alpha 1-Antitrypsin / analysis*


  • Insulin
  • alpha 1-Antitrypsin
  • Fructosamine