Abstract
Two novel cucurbitacins designated as neocucurbitacins A (1), possessing inhibitory activity of polyoma enhancer binding protein 2alphaA (PEBP2alphaA) and osteoclastogenesis-inhibitory factor (OCIF) gene expression in human osteoblast-like cells, and B (2) were isolated from the fruit of Luffa operculata. Their structures have been determined by extensive spectroscopic investigation.
MeSH terms
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Cell Line
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Core Binding Factor Alpha 2 Subunit
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Cucurbitaceae / chemistry*
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DNA-Binding Proteins / biosynthesis*
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DNA-Binding Proteins / genetics*
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Glycoproteins / biosynthesis*
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Glycoproteins / genetics*
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Humans
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Luffa / chemistry*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Osteoblasts / metabolism*
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Osteoprotegerin
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Plant Extracts / analysis
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Proto-Oncogene Proteins*
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
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Receptors, Cytoplasmic and Nuclear / biosynthesis*
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Receptors, Cytoplasmic and Nuclear / genetics*
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Receptors, Tumor Necrosis Factor
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Infrared
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Transcription Factors / biosynthesis*
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Transcription Factors / genetics*
Substances
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Core Binding Factor Alpha 2 Subunit
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DNA-Binding Proteins
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Glycoproteins
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Osteoprotegerin
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Plant Extracts
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Proto-Oncogene Proteins
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RNA, Messenger
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Receptors, Cytoplasmic and Nuclear
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Receptors, Tumor Necrosis Factor
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TNFRSF11B protein, human
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Transcription Factors