Retinoic acid metabolism

J Am Acad Dermatol. 2001 Nov;45(5):S136-42. doi: 10.1067/mjd.2001.113715.


The tissue distribution of retinoic acid (RA) throughout development is highly restricted, defined by the expression patterns of enzymes involved in RA synthesis and catabolism. Presented is a summary of recent research that examines the role of some of the enzymes involved in RA distribution, particularly those involved in RA catabolism (P450RAI). These latter enzymes protect against premature exposure to RA, and the implications of these findings are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Catalysis
  • Cytochrome P-450 Enzyme System / metabolism*
  • Humans
  • Keratolytic Agents / metabolism*
  • Keratolytic Agents / pharmacokinetics
  • Mixed Function Oxygenases / metabolism*
  • Neoplasms / drug therapy
  • Neoplasms / physiopathology
  • Retinoic Acid 4-Hydroxylase
  • Signal Transduction
  • Tretinoin / metabolism*
  • Tretinoin / pharmacokinetics
  • Vitamin A Deficiency / complications


  • Keratolytic Agents
  • Tretinoin
  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • Retinoic Acid 4-Hydroxylase