Uses and complications of isotretinoin therapy

J Am Acad Dermatol. 2001 Nov;45(5):S150-7. doi: 10.1067/mjd.2001.113717.


Isotretinoin (13-cis-retinoic acid) is a retinoid that has been used over the past 2 decades to treat a wide variety of dermatologic conditions, some with great success. Although it is beneficial in many skin conditions, the side effects and toxicities of oral retinoids require careful monitoring by experienced physicians. The clinical applications of oral retinoids continue to expand both within and beyond the field of dermatology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acne Vulgaris / drug therapy
  • Administration, Oral
  • Adult
  • Aged
  • Aging
  • Dermatologic Agents / adverse effects*
  • Dermatologic Agents / pharmacology
  • Dermatologic Agents / therapeutic use*
  • Humans
  • Isotretinoin / adverse effects*
  • Isotretinoin / pharmacology
  • Isotretinoin / therapeutic use*
  • Middle Aged
  • Psoriasis / drug therapy
  • Skin Diseases / drug therapy*
  • Skin Neoplasms / prevention & control


  • Dermatologic Agents
  • Isotretinoin