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, 92 (10), 4158-63

Function of the Oxidative Burst in Hypersensitive Disease Resistance

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Function of the Oxidative Burst in Hypersensitive Disease Resistance

R Tenhaken et al. Proc Natl Acad Sci U S A.

Abstract

Microbial elicitors or attempted infection with an avirulent pathogen strain causes the rapid production of reactive oxygen intermediates. Recent findings indicate that H2O2 from this oxidative burst plays a central role in the orchestration of the hypersensitive response: (i) as the substrate driving the cross-linking of cell wall structural proteins to slow microbial ingress prior to the deployment of transcription-dependent defenses and to trap pathogens in cells destined to undergo hypersensitive cell death, (ii) as a local threshold trigger of this programmed death in challenged cells, and (iii) as a diffusible signal for the induction in adjacent cells of genes encoding cellular protectants such as glutathione S-transferase and glutathione peroxidase. These findings provide the basis for an integrated model for the orchestration of the localized hypersensitive resistance response to attack by an avirulent pathogen.

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References

    1. Plant Physiol. 1989 May;90(1):109-16 - PubMed
    1. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7327-31 - PubMed
    1. J Biol Chem. 1992 Oct 5;267(28):20140-7 - PubMed
    1. Cell. 1992 Sep 18;70(6):879-86 - PubMed
    1. Cell. 1994 May 20;77(4):565-77 - PubMed

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