Abstract
c-MYC is the prototype for oncogene activation by chromosomal translocation. In contrast to the tightly regulated expression of c-myc in normal cells, c-myc is frequently deregulated in human cancers. Herein, aspects of c-myc gene activation and the function of the c-Myc protein are reviewed. The c-myc gene produces an oncogenic transcription factor that affects diverse cellular processes involved in cell growth, cell proliferation, apoptosis and cellular metabolism. Complete removal of c-myc results in slowed cell growth and proliferation, suggesting that while c-myc is not required for cell proliferation, it acts as an integrator and accelerator of cellular metabolism and proliferation.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Basic-Leucine Zipper Transcription Factors
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Burkitt Lymphoma / genetics
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Cell Adhesion
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Cell Differentiation
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Cell Division
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Cellular Senescence
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DNA-Binding Proteins / genetics
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Gene Expression Regulation, Neoplastic
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Genes, myc / genetics*
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Models, Genetic
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Models, Molecular
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Mutation
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Neoplasms / genetics*
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Neoplasms / metabolism*
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Protein Structure, Tertiary
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Proto-Oncogene Proteins c-myc / metabolism*
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Proto-Oncogene Proteins c-myc / physiology*
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Transcription Factors*
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Transcription, Genetic
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Transcriptional Activation
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Translocation, Genetic*
Substances
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Basic-Leucine Zipper Transcription Factors
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DNA-Binding Proteins
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Myc associated factor X
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Proto-Oncogene Proteins c-myc
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Transcription Factors