Peroxisome Proliferator-Activated Receptor (PPAR) Modulators: Diabetes and Beyond

Med Res Rev. 2001 Nov;21(6):540-52. doi: 10.1002/med.1025.


Peroxisome proliferator-activated receptors (PPARs) are a class of ligand modulated transcription factors with a prominent role in the regulation of metabolic processes. This report is intended to provide a limited introduction to the PPAR field, sketched with reference to one early series of PPAR ligands.

Publication types

  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2 / metabolism*
  • Humans
  • Receptors, Cytoplasmic and Nuclear / drug effects*
  • Transcription Factors / drug effects*


  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors