Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis. A new syndrome

Am J Med. 1975 Sep;59(3):325-33. doi: 10.1016/0002-9343(75)90390-3.


We describe two patients with a unique granulomatous syndrome who presented with renal failure secondary to diffuse eosinophilic interstitial nephritis. Both had bilateral anterior uveitis, bone marrow granulomas, hypergammaglobulinemia and an increased sedimentation rate. One patient had lymph node granulomas and an immunoglobulin G (IgG) rheumatoid factor. An extensive investigation for an etiologic agent was unrewarding, and neither patient could be placed into any existing diagnostic category. Over a period of 2 years both patients have experienced improved renal function and dissolution of their bone marrow granulomas.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Kidney Injury / complications*
  • Adolescent
  • Biopsy
  • Blood Sedimentation
  • Bone Marrow Diseases / complications*
  • Bone Marrow Examination
  • Female
  • Granuloma / complications*
  • Humans
  • Kidney / pathology
  • Lymphatic Diseases / complications*
  • Nephritis, Interstitial / complications*
  • Syndrome
  • Uveitis / complications*