Reduction of endotoxin levels in influenza virus vaccines by barium sulfate adsorption-elution

P S Reichelderfer; J F Manischewitz; M A Wells; H D Hochstein; F A Ennis

doi:10.1128/am.30.2.333-334.1975

Reduction of endotoxin levels in influenza virus vaccines by barium sulfate adsorption-elution

Appl Microbiol. 1975 Aug;30(2):333-4. doi: 10.1128/am.30.2.333-334.1975.

Authors

P S Reichelderfer, J F Manischewitz, M A Wells, H D Hochstein, F A Ennis

Abstract

The level of endotoxin in influenza virus vaccine lots was reduced 10- to 20-fold after barium sulfate adsorption-elution. The amount of viral antigen lost was negligible.

MeSH terms

Adsorption
Antigens, Viral / analysis
Barium Sulfate*
Drug Contamination
Endotoxins / isolation & purification*
Influenza Vaccines / isolation & purification*
Methods
Orthomyxoviridae / immunology

Substances

Antigens, Viral
Endotoxins
Influenza Vaccines
Barium Sulfate