Isolated limb perfusion: the European experience

Surg Oncol Clin N Am. 2001 Oct;10(4):821-32, ix.


Isolated limb perfusion (ILP) is a method of cancer treatment allowing the administration of high doses of anticancer agents in a limb surgically isolated from systemic circulation. By using continuous leakage monitoring and using the drug melphalan, a high complete remission rate is obtained in patients with melanoma. In patients with sarcomas, ILP with tumor necrosis factor and melphalan represents a neoadjuvant treatment for limb-sparing surgery. This treatment is the first demonstration of an active anti-angiogenic regimen in the clinic.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Chemotherapy, Cancer, Regional Perfusion*
  • Europe
  • Humans
  • Interferon-gamma / administration & dosage
  • Melanoma / drug therapy*
  • Melanoma / secondary
  • Sarcoma / drug therapy
  • Soft Tissue Neoplasms / drug therapy
  • Tumor Necrosis Factor-alpha / administration & dosage


  • Antineoplastic Agents
  • Tumor Necrosis Factor-alpha
  • Interferon-gamma