Correlation of quantitative protein measurements in 8-, 12-, and 24-hour urine samples for the diagnosis of preeclampsia

Am J Obstet Gynecol. 2001 Oct;185(4):804-7. doi: 10.1067/mob.2001.117302.


Objective: The purpose of this study is to determine if a patient's 8- and/or 12-hour urine total protein values correlate with the 24- hour value to confirm the diagnosis of preeclampsia.

Study design: The study population included 65 patients with hypertensive disorders of pregnancy. Patients' urine was collected over 24 hours with the first 8 hours, next 4 hours, and remaining 12 hours collected in separate containers. The urine volume, and total protein and creatinine levels were measured in the 8-, 12-, and 24-hour samples. The 8- and 12-hour results were compared to the 24-hour results by use of simple regression analysis.

Results: Of the 65 patients, 20 had no proteinuria, 37 had mild proteinuria, and 8 had severe proteinuria. The results of the 8- hour sample correlated with those of the 24-hour sample for patients with mild (P <.001) and severe disease (P =.003). The 12-hour sample correlated with the 24-hour sample for patients with no disease (P <.001), mild proteinuria (P <.001), and severe proteinuria (P =.0003).

Conclusion: Total protein values for 8- and 12-hour urine samples correlate positively with values for 24-hour samples for patients with proteinuria. The results for 12- and 24-hour samples correlate for patients without proteinuria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analysis of Variance
  • Female
  • Gestational Age
  • Humans
  • Hypertension / complications
  • Hypertension / diagnosis*
  • Pre-Eclampsia / diagnosis*
  • Pre-Eclampsia / etiology
  • Predictive Value of Tests
  • Pregnancy
  • Probability
  • Prospective Studies
  • Proteinuria / diagnosis*
  • Regression Analysis
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Time Factors
  • Urinalysis