The angiotensin II type 1 receptor and receptor-associated proteins

Cell Res. 2001 Sep;11(3):165-80. doi: 10.1038/


The mechanisms of regulation, activation and signal transduction of the angiotensin II (Ang II) type 1 (AT1) receptor have been studied extensively in the decade after its cloning. The AT1 receptor is a major component of the renin-angiotensin system (RAS). It mediates the classical biological actions of Ang II. Among the structures required for regulation and activation of the receptor, its carboxyl-terminal region plays crucial roles in receptor internalization, desensitization and phosphorylation. The mechanisms involved in heterotrimeric G-protein coupling to the receptor, activation of the downstream signaling pathway by G proteins and the Ang II signal transduction pathways leading to specific cellular responses are discussed. In addition, recent work on the identification and characterization of novel proteins associated with carboxyl-terminus of the AT1 receptor is presented. These novel proteins will advance our understanding of how the receptor is internalized and recycled as they provide molecular mechanisms for the activation and regulation of G-protein-coupled receptors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Amino Acid Sequence
  • Animals
  • Carrier Proteins / chemistry
  • Carrier Proteins / metabolism*
  • Cell Line
  • Endocytosis / physiology
  • Gene Expression Regulation / physiology
  • Heterotrimeric GTP-Binding Proteins / metabolism*
  • Humans
  • Molecular Sequence Data
  • Protein Structure, Tertiary
  • Protein Transport / physiology
  • Receptor, Angiotensin, Type 1
  • Receptors, Angiotensin / chemistry
  • Receptors, Angiotensin / genetics
  • Receptors, Angiotensin / metabolism*
  • Recombinant Fusion Proteins / metabolism
  • Renin-Angiotensin System / physiology
  • Sequence Alignment
  • Signal Transduction / physiology*


  • Adaptor Proteins, Signal Transducing
  • Agtrap protein, mouse
  • Carrier Proteins
  • Receptor, Angiotensin, Type 1
  • Receptors, Angiotensin
  • Recombinant Fusion Proteins
  • Heterotrimeric GTP-Binding Proteins