A case of polymyositis with anti-histidyl-t-RNA synthetase (Jo-1) antibody syndrome following extensive vinyl chloride exposure

Clin Rheumatol. 2001;20(5):379-82. doi: 10.1007/s100670170032.


Occupational exposure to vinyl chloride monomers is known to induce Raynaud's phenomenon, periportal fibrosis, liver angiosarcoma and scleroderma-like syndrome. We report the first case of occupational polymyositis in a 58-year-old man exposed to vinyl chloride. A dysimmune process was strongly suspected as having induced vinyl chloride disease. Our patient had an anti-histidyl-t-RNA-synthetase (Jo1) antibody, which has never to our knowledge been reported in this occupational disease.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Antinuclear / analysis
  • Antibodies, Antinuclear / immunology*
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Occupational Diseases / chemically induced*
  • Occupational Diseases / immunology
  • Occupational Exposure / adverse effects*
  • Polymyositis / chemically induced*
  • Polymyositis / diagnosis
  • Risk Assessment
  • Syndrome
  • Time Factors
  • Vinyl Chloride / adverse effects*


  • Antibodies, Antinuclear
  • Jo-1 antibody
  • Vinyl Chloride