Antagonism by baclophen of the d-amphetamine-induced disruption of a successive discrimination in the rat

J Neural Transm. 1975;36(3-4):327-33. doi: 10.1007/BF01253132.


Male rats were trained to performa conditioned avoidance response combined with a successive discrimination in a shuttle-box. The administration of -amphetamine, 4 mg/kg i.p., caused a disruption of the discriminative but not thee avoidance behavior. Baclophen (beta-[-4-clorophenyl]-psi-aminobutyric acid), a GBA-derivative, given in a dose (4 mg/kg i.p.) that had no effect per se on the behavior in this test situation antagonized the -amphetamine-induced hypermotility. The present findins that baclophen antagonized a biochemically induced abnormal behaviour point to an "antipsychotic" action of baclophen in a successive discrimination avoidance test.

MeSH terms

  • Aminobutyrates / pharmacology*
  • Animals
  • Avoidance Learning / drug effects
  • Baclofen / administration & dosage
  • Baclofen / pharmacology*
  • Dextroamphetamine / administration & dosage
  • Dextroamphetamine / antagonists & inhibitors
  • Dextroamphetamine / pharmacology*
  • Discrimination, Psychological / drug effects*
  • Drug Combinations
  • Male
  • Rats


  • Aminobutyrates
  • Drug Combinations
  • Baclofen
  • Dextroamphetamine