Animal infection models and ethics -- the perfect infection model

J Antimicrob Chemother. 1993 May;31(Suppl. D):193-205. doi: 10.1093/jac/31.suppl_d.193.


Experimental infection models have long been recognized as an essential part of testing anti-infective therapies. A perfect animal model would be a model that satisfied not only scientific criteria, but ethical criteria as well. In the design and execution of such experiments, scientific and ethical considerations are not mutually exclusive, but should be convergent and therefore result in the optimal model.

Publication types

  • Review

MeSH terms

  • Animal Experimentation*
  • Animal Rights
  • Animal Testing Alternatives
  • Animal Welfare*
  • Animals
  • Bacterial Infections / drug therapy*
  • Disease Models, Animal*
  • Ethics*
  • Human Rights
  • Humans
  • Moral Obligations
  • Pharmaceutical Preparations
  • Research Design
  • Research Personnel
  • Risk
  • Risk Assessment
  • Social Responsibility
  • Stress, Psychological


  • Pharmaceutical Preparations