Diagnostic value of disaccharide tolerance tests in children

Acta Paediatr Scand. 1975 Sep;64(5):693-8. doi: 10.1111/j.1651-2227.1975.tb03906.x.


Diagnostic value of disaccharide tolerance tests in children. Acta Paediatr Scand, 64:693, 1975.--The diagnostic value of oral lactose and sucrose tolerance tests was investigated in 61 children. A total of 105 oral disaccharide tests were carried out. When the rise in blood sugar was low, the same disaccharide was, as a control measure, instilled directly into the small intestine through a tube. This was carried out in 40 cases. In 21 patients the rise in blood sugar following the two forms of administration was correlated with the disaccharidase activity in a peroral small-intestine biopsy. The incidence of false-positive oral lactose tests was between 23 and 30%, that of false-positive oral sucrose tests between 24 and 33%. A border value of 20 mg per 100 ml in the rise of blood glucose within the first hour following a direct intra-intestinal administration affords a very satisfactory distinction between patients with and without disaccharide malabsorption. Blood glucose determinations exceeding one hour were found to be without diagnostic value.

MeSH terms

  • Adolescent
  • Blood Glucose / metabolism
  • Celiac Disease / diagnosis
  • Child
  • Child, Preschool
  • Evaluation Studies as Topic
  • False Positive Reactions
  • Female
  • Humans
  • Infant
  • Intestine, Small / enzymology
  • Intestine, Small / metabolism
  • Lactose / metabolism
  • Lactose Tolerance Test*
  • Malabsorption Syndromes / diagnosis
  • Male
  • Sucrase / metabolism
  • Sucrose* / metabolism
  • Time Factors


  • Blood Glucose
  • Sucrose
  • Sucrase
  • Lactose