The gene encoding interleukin-13: a susceptibility locus for asthma and related traits

Respir Res. 2000;1(1):19-23. doi: 10.1186/rr7. Epub 2000 Jul 17.


Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene cluster on chromosome 5q as a susceptibility locus for asthma. Recently, the Th2 cytokine interleukin-13 has been shown to be a critical mediator of the asthma phenotype in murine models. In this commentary we discuss several recent studies that have identified polymorphisms in the gene encoding interleukin-13. The consistent genetic associations of interleukin-13 with asthma and related traits across diverse ethnic populations in these studies provides strong support for the candidacy of this cytokine as a susceptibility locus for asthma and atopy on chromosome 5q31.

Publication types

  • Review

MeSH terms

  • Asthma / genetics*
  • Chromosomes, Human, Pair 5 / genetics
  • Genetic Predisposition to Disease*
  • Humans
  • Hypersensitivity / genetics*
  • Interleukin-13 / genetics*


  • Interleukin-13