Oxygen-regulated transcription factors and their role in pulmonary disease

Respir Res. 2000;1(3):159-62. doi: 10.1186/rr27. Epub 2000 Nov 9.


The transcription factors nuclear factor interleukin-6 (NF-IL6), early growth response-1 (EGR-1) and hypoxia-inducible factor-1 (HIF-1) have important roles in the molecular pathophysiology of hypoxia-associated pulmonary disease. NF-IL6 controls the production of interleukin (IL)-6 in vascular endothelial cells, which may have anti-inflammatory activity by counteracting effects of IL-1 and IL-8. EGR-1 controls the production of tissue factor by macrophages, which triggers fibrin deposition in the pulmonary vasculature. HIF-1 activates the expression of the vasoconstrictor endothelin-1 in vascular endothelial cells. Angiotensin II induces HIF-1 expression and hypertrophy of pulmonary arterial smooth muscle cells. HIF-1 might therefore have multiple roles in the pathogenesis of pulmonary vascular remodeling.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • CCAAT-Enhancer-Binding Protein-beta / metabolism
  • DNA-Binding Proteins / metabolism
  • Hypoxia-Inducible Factor 1
  • Lung Diseases / metabolism*
  • Nuclear Proteins / metabolism
  • Oxygen / metabolism*
  • Transcription Factors / metabolism*


  • CCAAT-Enhancer-Binding Protein-beta
  • DNA-Binding Proteins
  • Hypoxia-Inducible Factor 1
  • Nuclear Proteins
  • Transcription Factors
  • Oxygen