Synthesis of Dihydroisoxazole Nucleoside and Nucleotide Analogs

Hung-Jang Gi; Yuejun Xiang; Raymond F. Schinazi; Kang Zhao

doi:10.1021/jo961779r

Synthesis of Dihydroisoxazole Nucleoside and Nucleotide Analogs

J Org Chem. 1997 Jan 10;62(1):88-92. doi: 10.1021/jo961779r.

Authors

Hung-Jang Gi¹, Yuejun Xiang, Raymond F. Schinazi, Kang Zhao

Affiliation

¹ Department of Chemistry, New York University, New York, New York 10003, Georgia Research Center for AIDS and HIV Infections, Veterans Affairs Medical Center, Decatur, Georgia 30033, and Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322.

PMID: 11671367
DOI: 10.1021/jo961779r

Abstract

The dihydroisoxazole nucleosides as well as their phosphonate derivatives were efficiently prepared via 1,3-dipolar cycloaddition reactions of nitrile oxides with corresponding vinyl nucleoside bases for antiviral studies.