Signaling takes a breath--new quantitative perspectives on bioenergetics and signal transduction

Immunity. 2001 Oct;15(4):497-502. doi: 10.1016/s1074-7613(01)00205-9.


Immune cells are in constant need of energy for both basic housekeeping and specific immune functions. Increased energy demand during lymphocyte stimulation is coordinated by signal transduction pathways. This review explores the interface between lymphocyte signaling and energy metabolism. In particular, it discusses recent work that allows weighing signaling routes with respect to their role in the regulation of energy metabolism during lymphocyte activation.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Calcineurin / physiology
  • Calcium Signaling
  • Energy Metabolism
  • Humans
  • Lymphocyte Activation
  • MAP Kinase Signaling System
  • Models, Immunological
  • Protein Kinase C / physiology
  • Rats
  • Signal Transduction*
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism*


  • Adenosine Triphosphate
  • Protein Kinase C
  • Calcineurin