Transforming growth factor beta enhances the expression of CD154 (CD40L) and production of tumor necrosis factor alpha by human T lymphocytes

Immunol Lett. 2001 Sep 3;78(2):83-8. doi: 10.1016/s0165-2478(01)00233-4.


Activation of lymphocytes in the presence of transforming growth factor beta (TGFbeta) can impair or enhance their functional activity. We have found that TGFbeta is important in the generation of lymphocytes, which are capable of suppressing antibody production. To better understand how this cytokine affects lymphocyte activity, we looked at the expression of early activation events of T cells stimulated in the presence or absence of TGFbeta. The results show that TGFbeta enhances the expression of CD154 (CD40L), TNFR2 and the production of TNFalpha. These findings clarify the co-stimulatory effects of TGFbeta that enhance T lymphocyte activation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • CD40 Ligand / biosynthesis*
  • Cells, Cultured
  • Concanavalin A / pharmacology
  • Humans
  • Interphase / immunology
  • Receptors, Tumor Necrosis Factor / biosynthesis
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism*
  • Transforming Growth Factor beta / physiology*
  • Tumor Necrosis Factor-alpha / biosynthesis*
  • Up-Regulation / immunology*


  • Receptors, Tumor Necrosis Factor
  • Transforming Growth Factor beta
  • Tumor Necrosis Factor-alpha
  • Concanavalin A
  • CD40 Ligand