FISH characterization of t(8;12)(q12;p13) observed as the sole karyotypic anomaly in a myelodysplastic syndrome patient

P Finelli; N S Fracchiolla; D Giardino; G Gottardi; D L Deliliers; A Cortelezzi; L Larizza; G L Deliliers

doi:10.1016/s0165-4608(01)00456-3

FISH characterization of t(8;12)(q12;p13) observed as the sole karyotypic anomaly in a myelodysplastic syndrome patient

Cancer Genet Cytogenet. 2001 Oct 1;130(1):75-8. doi: 10.1016/s0165-4608(01)00456-3.

Authors

P Finelli¹, N S Fracchiolla, D Giardino, G Gottardi, D L Deliliers, A Cortelezzi, L Larizza, G L Deliliers

Affiliation

¹ Laboratorio di Citogenetica, Istituto Auxologico Italiano, Laboratorio di Citogenetica, Via San Vittore 45, 20123, Milan, Italy. finelli@auxologico.it

PMID: 11672778
DOI: 10.1016/s0165-4608(01)00456-3

Abstract

We report a t(8;12)(q12; p13) as the sole cytogenetic anomaly in a patient with a myelodysplastic syndrome (MDS). By means of FISH, we mapped the genomic region involved in the breakpoint (bkp) on both chromosomes. The 12p13 bkp mapped between markers WI-664 and WI-9218, immediately distal to the breakpoint cluster region frequently involved in hematological neoplasms targeted by y964C10. The 8q12 bkp (not yet investigated by FISH) was characterized and found to occur between markers WI-3263 and D8S524 within the region recognized by y874E10.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Chromosomes, Artificial, Yeast
Chromosomes, Human, Pair 12*
Chromosomes, Human, Pair 8*
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Myelodysplastic Syndromes / genetics*
Translocation, Genetic*