C-reactive protein is independently associated with total body fat, central fat, and insulin resistance in adult women

Int J Obes Relat Metab Disord. 2001 Oct;25(10):1416-20. doi: 10.1038/sj.ijo.0801719.


Objective: To investigate whether C-reactive protein (CRP) concentrations are influenced by body composition, insulin resistance, and body fat distribution in healthy women.

Design: Cross-sectional study of CRP plasma levels in adult women.

Subjects: A total of 201 apparently healthy normal weight, overweight, and obese women, aged 18-60 y.

Measurements: CRP plasma levels, several fatness and body fat distribution parameters (by bioimpedance analysis and anthropometry), and insulin resistance (HOMA(IR)), as calculated by homeostatic model assessment.

Results: CRP was positively correlated with age, body mass index (BMI), waist, fasting glucose and insulin, HOMA(IR), fat-free mass (FFM) and fat mass (FM). After multivariate analyses, age, HOMA(IR), waist and FM maintained their independent association with CRP.

Conclusion: Our study has shown an independent relationship of central fat accumulation and insulin resistance with CRP plasma levels, thus suggesting that mild, chronic inflammation may be a further component of the metabolic syndrome and a mediator of the atherogenic profile of this syndrome.

Publication types

  • Comparative Study

MeSH terms

  • Abdomen
  • Adipose Tissue / anatomy & histology*
  • Adolescent
  • Adult
  • Age Factors
  • Anthropometry
  • Arteriosclerosis / blood
  • Arteriosclerosis / etiology*
  • Arteriosclerosis / immunology
  • Body Composition
  • Body Mass Index
  • C-Reactive Protein / analysis*
  • Cross-Sectional Studies
  • Electric Impedance
  • Female
  • Humans
  • Insulin / blood*
  • Insulin Resistance
  • Metabolic Syndrome / immunology*
  • Middle Aged
  • Obesity / blood*
  • Obesity / immunology


  • Insulin
  • C-Reactive Protein