Syk expression and novel function in a wide variety of tissues

Biochem Biophys Res Commun. 2001 Nov 2;288(3):495-8. doi: 10.1006/bbrc.2001.5788.


Syk protein-tyrosine kinase has been implicated in a variety of hematopoietic cell responses, in particular immunoreceptor signaling events that mediate diverse cellular responses including proliferation, differentiation, and phagocytosis. On the other hand, Syk exhibits a more widespread expression pattern in nonhematopoietic cells like fibroblasts, epithelial cells, breast tissue, hepatocytes, neuronal cells, and vascular endothelial cells and has been shown to be functionally important on these cell types. Thus, Syk appears to play a general physiological function in a wide variety of cells. In this article, we briefly review the current literature regarding the expression and novel function of Syk in various cells and tissues.

Publication types

  • Review

MeSH terms

  • Animals
  • Endothelium, Vascular / metabolism
  • Enzyme Precursors / metabolism*
  • Epithelial Cells / metabolism
  • Fibroblasts / metabolism
  • Hepatocytes / metabolism
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Neurons / metabolism
  • Protein-Tyrosine Kinases / metabolism*
  • Syk Kinase
  • Tissue Distribution


  • Enzyme Precursors
  • Intracellular Signaling Peptides and Proteins
  • Protein-Tyrosine Kinases
  • SYK protein, human
  • Syk Kinase