DAF-7/TGF-beta expression required for the normal larval development in C. elegans is controlled by a presumed guanylyl cyclase DAF-11

Mech Dev. 2001 Nov;109(1):27-35. doi: 10.1016/s0925-4773(01)00507-x.


In C. elegans development, unfavorable growth conditions lead a larva to an arrested and enduring form called a dauer. To elucidate components upstream of DAF-7/TGF-beta in this control pathway, we isolated a mutant that was defective in daf-7 promoter::gfp reporter expression and showed an arrested (dauer-constitutive) phenotype. It has a new mutation in the daf-11 gene encoding a transmembrane guanylyl cyclase. We show that daf-11 gene and a related gene daf-21 act upstream of daf-7, and cilium-related genes che-2 and che-3 are placed between daf-11 and daf-7, in the genetic pathway controlling dauer formation. Expression of daf-11 cDNA by cell specific promoters suggests that daf-11 acts cell autonomously in ASI chemosensory neurons for daf-7 expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Animals
  • Artificial Gene Fusion
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans / growth & development
  • Caenorhabditis elegans / metabolism
  • Caenorhabditis elegans Proteins*
  • Gene Expression Regulation*
  • Green Fluorescent Proteins
  • Guanylate Cyclase / genetics
  • Guanylate Cyclase / metabolism*
  • Helminth Proteins / genetics*
  • Larva / growth & development
  • Luminescent Proteins / genetics
  • Mutagenesis
  • Neurons
  • Phenotype
  • Promoter Regions, Genetic
  • Transforming Growth Factor beta / genetics*


  • Caenorhabditis elegans Proteins
  • DAF-7 protein, C elegans
  • Helminth Proteins
  • Luminescent Proteins
  • Transforming Growth Factor beta
  • Green Fluorescent Proteins
  • Guanylate Cyclase