CD4(+) regulatory T cells

Curr Opin Immunol. 2001 Dec;13(6):644-9. doi: 10.1016/s0952-7915(01)00273-4.


There is now compelling evidence that CD4(+) T cells that specialize in the suppression of immune responses play a key role in the control of immune pathology. Recently, there have been a number of reports that have provided information on the generation of CD4(+) regulatory T cells in the thymus and in the periphery. These cells have also been identified in humans, paving the way for analysis of the function of CD4(+) regulatory T cells in immune-mediated disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Adhesion
  • Cytokines / physiology
  • Humans
  • Lymphocyte Activation
  • Mice
  • Receptors, Interleukin-2 / analysis
  • T-Lymphocyte Subsets / classification
  • T-Lymphocytes, Regulatory / immunology*
  • Thymus Gland / immunology


  • Cytokines
  • Receptors, Interleukin-2