(+)-epi-Alpha-bisabolol [correction of bisbolol] is the wound-healing principle of Peperomia galioides: investigation of the in vivo wound-healing activity of related terpenoids

J Nat Prod. 2001 Oct;64(10):1357-9. doi: 10.1021/np0102859.

Abstract

Bioassay-guided investigation of the ethanol extract of Peperomia galioides using a tensile strength method in mice as a monitor led to the isolation of epi-alpha-bisabolol (1) (ED(50) 155 microg/mL). An in vivo healing study of selected commercially available monoterpenoids yielded two bioactive compounds, alpha-bisabolol (2) and alpha-terpineol (3) (ED(50) of 228 and 240 microg/g mouse[corrected], respectively).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 3T3 Cells / drug effects
  • Animals
  • Chromatography, High Pressure Liquid
  • Cyclohexane Monoterpenes
  • Cyclohexenes
  • Farnesol / pharmacology
  • Fibroblasts / drug effects
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • Monocyclic Sesquiterpenes
  • Monoterpenes*
  • Peru
  • Piperaceae / chemistry*
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification*
  • Plant Extracts / pharmacology
  • Plants, Medicinal / chemistry
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Stereoisomerism
  • Structure-Activity Relationship
  • Terpenes / pharmacology
  • Toxicity Tests
  • Wound Healing

Substances

  • Cyclohexane Monoterpenes
  • Cyclohexenes
  • Monocyclic Sesquiterpenes
  • Monoterpenes
  • Plant Extracts
  • Sesquiterpenes
  • Terpenes
  • alpha-terpineol
  • bisabolol
  • Farnesol