Lessons from interleukin-deficient mice: the interleukin-1 system

Acta Physiol Scand. 2001 Sep;173(1):5-9. doi: 10.1046/j.1365-201X.2001.00879.x.

Abstract

The study of cytokine-deficient mice has provided important information for a better understanding of inflammatory processes. In this report, the characterization of mice deficient for various components of the interleukin (IL)-1 system is reviewed. Results obtained by studying mice deficient for IL-1alpha, IL-1beta, IL-1 receptor antagonist, IL-1 receptor type I, IL-1 receptor accessory protein, IL-1 receptor-associated kinase, and the IL-1beta-converting enzyme caspase-1 are summarized. Because some of the components of the IL-1 system are shared with IL-18, similarities between IL-1beta and IL-18 are also discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Caspase 1 / genetics
  • Caspase 1 / immunology
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1 / genetics*
  • Interleukin-1 / immunology*
  • Interleukin-1 Receptor-Associated Kinases
  • Interleukin-18 / immunology
  • Mice
  • Mice, Transgenic
  • Protein Kinases / genetics
  • Protein Kinases / immunology
  • Receptors, Interleukin-1 / genetics*
  • Receptors, Interleukin-1 / immunology*
  • Sialoglycoproteins / genetics
  • Sialoglycoproteins / immunology

Substances

  • Il1rn protein, mouse
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1
  • Interleukin-18
  • Receptors, Interleukin-1
  • Sialoglycoproteins
  • Protein Kinases
  • Interleukin-1 Receptor-Associated Kinases
  • Caspase 1