Sentinel node biopsy in the management of malignant melanoma

Clin Exp Dermatol. 2001 Sep;26(6):463-8. doi: 10.1046/j.1365-2230.2001.00868.x.


The technique of sentinel lymph node (SLN) biopsy has been in use for almost a decade, but its effect on survival has not yet been established. It is however the most accurate method for staging patients with primary cutaneous melanoma who lack clinical evidence of metastatic disease. This article discusses the rationale and logistics of SLN biopsy, and the management strategies that can be employed in those patients who are SLN positive. Future therapeutic trial in patients with primary cutaneous melanoma will only be meaningful if the SLN status of the subjects is established.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / analysis
  • Humans
  • Immunohistochemistry
  • Melanoma / pathology*
  • Neoplasm Staging
  • S100 Proteins / analysis
  • Sentinel Lymph Node Biopsy / methods*
  • Skin Neoplasms / pathology*


  • Biomarkers, Tumor
  • S100 Proteins