Cognitive function and information processing in type 2 diabetes

Diabet Med. 2001 Oct;18(10):803-10. doi: 10.1046/j.1464-5491.2001.00577.x.


Aims: To determine whether uncomplicated Type 2 diabetes is associated with impairment of cognitive function and information processing ability.

Methods: Thirty-eight participants with uncomplicated Type 2 diabetes and 38 non-diabetic controls were studied. The two groups were comparable for age and premorbid intellectual ability, and did not have other medical disorders likely to affect cognitive function. An extensive battery of tests was administered which assessed different levels and domains of cognitive functions including verbal and visual memory, executive function, general mental ability and efficiency of information processing.

Results: No significant differences were found between the diabetic and control groups on any measure of cognitive function or information processing. The performance on these tests was not associated with recent glycaemic control (assessed by HbA1c). Duration of diabetes, however, correlated significantly with poorer performance on several measures of verbal memory.

Conclusions: The results of the present study suggest that some aspect of Type 2 diabetes (as indexed by the estimated duration of the disorder) does relate significantly to cognitive function within the group with diabetes. However, other diabetes-related factors, such as macrovascular disease, hypertension and depression, may contribute more to previously observed cognitive decrements in Type 2 diabetes.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Age of Onset
  • Alcohol Drinking
  • Choice Behavior
  • Cognition*
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / physiopathology
  • Diabetes Mellitus, Type 2 / psychology*
  • Educational Status
  • Evoked Potentials
  • Female
  • Glycated Hemoglobin A / analysis
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Male
  • Memory / physiology
  • Mental Processes / physiology*
  • Middle Aged
  • Motor Activity / physiology
  • Reaction Time
  • Reading
  • Reference Values
  • Time Factors
  • Vision, Ocular / physiology
  • Wechsler Scales


  • Glycated Hemoglobin A
  • Hypoglycemic Agents