The vitamin D receptor gene variant is associated with the prevalence of type 2 diabetes mellitus and coronary artery disease

Diabet Med. 2001 Oct;18(10):842-5. doi: 10.1046/j.1464-5491.2001.00585.x.

Abstract

Aims: Vitamin D can influence lipolysis and insulin secretion. A common genetic polymorphism of the vitamin D receptor, which has been found to be associated with bone mineral density, has also been reported to be associated with insulin-dependent diabetes mellitus. To test the influence of the vitamin D receptor polymorphism on the prevalence of Type 2 diabetes mellitus and coronary artery disease we studied a population of high-risk patients, who were referred to our clinic for diagnostic coronary angiography.

Methods: A total of 293 patients considered at high risk for coronary artery disease because of angina pectoris and known hypercholesterolaemia underwent diagnostic coronary angiography. The BsmI vitamin D receptor polymorphism was analysed by polymerase chain reaction.

Results: Prevalence of Type 2 diabetes mellitus and coronary artery disease was gradually dependent on the number of B alleles (BB 28%, Bb 13%, bb 8% for Type 2 diabetes mellitus, P = 0.002; BB 88% Bb 72%, bb 66% coronary artery disease, P = 0.01). Patients with the BB genotype had an odds ratio of 3.64 (95% confidence interval 1.53-8.55, P = 0.002) to have Type 2 diabetes mellitus compared with patients with the bb genotype.

Conclusions: The genotype of the vitamin D receptor polymorphism determines the prevalence of Type 2 diabetes mellitus and coronary artery disease in a high-risk cohort population.

MeSH terms

  • Coronary Angiography
  • Coronary Disease / diagnostic imaging
  • Coronary Disease / genetics*
  • Cross-Sectional Studies
  • DNA / blood
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / genetics*
  • Female
  • Genetic Carrier Screening
  • Genetic Variation*
  • Genotype
  • Germany / epidemiology
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • Receptors, Calcitriol / genetics*
  • Smoking

Substances

  • Receptors, Calcitriol
  • DNA